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One-year follow-up of efficacy and cost of repeated doses versus single larger dose of intra-articular hyaluronic acid for knee osteoarthritis

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dc.contributor.authorVijaya Kumar L Suppan
dc.contributor.authorMei Mei Tew
dc.contributor.authorBor Chern Wong
dc.contributor.authorHuan Keat Chan
dc.contributor.authorYu Wei Chew
dc.contributor.authorChin Siong Tan
dc.contributor.authorVijay Kumar Nanta Kumar
dc.contributor.authorAsrul Akmal Shafie
dc.contributor.authorAshutosh Sadashiva Rao
dc.date.accessioned2024-09-07T10:15:35Z
dc.date.available2024-09-07T10:15:35Z
dc.date.issued2020
dc.description.abstractPurpose: A recent 3-month randomized, open-label controlled trial found that the intra-articular hyaluronic acid injection (GO-ON®) given as a single dose of 5 mL is as effective and safe as three repeated doses of 2.5 mL in patients with knee osteoarthritis. However, the information on the long-term efficacy and economic implications of the single dose regimen is still limited. Hence, this follow-up study was designed to compare the effectiveness and costs of the two regimens 12 months following the treatment. Methods: All the 127 patients, who received either three repeated doses (n ¼ 64) or a single dose (n ¼ 63) of GO-ON in the previous trial, were followed up in month 12 following the treatment. The effectiveness of both the regimens was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the mean WOMAC scores were compared with those recorded at the baseline and in month 3. Additionally, the total treatment costs of the two regimens, taking account of both direct and indirect costs, were computed and compared. Results: A total of 125 patients (98.4%) completed the assessment. Despite the reduction of the overall mean WOMAC score from 39.24 to 19.93 (p < 0.001) in the first 3 months following the treatment with GO-ON, no further changes were observed up to month 12 (p > 0.95). In the meantime, the two regimens did not differ in the mean WOMAC scores (p ¼ 0.749) and in the subscale scores for pain (p ¼ 0.970), stiffness (p ¼ 0.526), and physical functioning (p ¼ 0.667) in month 12. The cost for single-dose injection was found to be approximately 30% lower compared to the repeated doses. Conclusion: These findings indicate that the single larger dose of GO-ON is as effective as the repeated doses over 12 months, and yet the total treatment cost is lowered.
dc.identifier.doihttps://doi.org/10.1177/2309499019895029
dc.identifier.urihttps://journals.sagepub.com/doi/10.1177/2309499019895029?icid=int.sj-full-text.similar-articles.1
dc.identifier.urihttps://repository.nih.gov.my/handle/123456789/1076
dc.language.isoen
dc.relation.ispartofJournal of Orthopaedic Surgery
dc.relation.journalJournal of Orthopaedic Surgery
dc.subjectCosts and cost analysis
dc.subjectInjection
dc.subjectKnee
dc.subjectOsteoarthritis
dc.titleOne-year follow-up of efficacy and cost of repeated doses versus single larger dose of intra-articular hyaluronic acid for knee osteoarthritis
dc.typejournal-article
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume28
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