Welcome to NIH Research Digital Repository System


The NIH Research Digital Repository System is a dedicated platform designed for NIH to manage its institutional research materials. Its main objective is to provide a centralized hub to enable the institution to collect, protect, and distribute its scientific and intellectual contributions to ensure the visibility and long-term preservation of the intellectual assets of the institution.

Research outputs
218
Projects
0
People
0
Recent Additions
  • Publication
    Discuss on the Significance of Hepatitis B Virus Genotypes
    (Kuala Lumpur: Institute for Medical Research, 2011)
    Patchareeya Banchuen
    Hepatitis B virus (HBV) infection is a global health problem and the clinical outcome of chronic HBV infection depends on the frequency and severity of hepatitis flares in the immune clearance phase. At present, thirty four subgenotypes and ten genotypes (A-J) of HBV are identified and most have specific geographic distributions. The impact of these HBV genotypes on the clinical outcome of chronic HBV infection needs to be further clarified.
  • Publication
    Biosurveillance as a Tool for Early Detection Biothreat
    (Kuala Lumpur: Institute for Medical Research, 2011)
    Nurasykin Bt Salim
    The purpose of this article is to discuss biosurveillance as tool for early detection of biothreat. In order for me to complete this task, I have seek references from library books, online books, journals and websites of trusted source such as the official website of U.S Center for Disease Control and Prevention (CDC), U.S Department of Homeland Security and Oxford Dictionaries Online. I have also arranged this article into 7 parts. Part I consists of the introduction that briefs how I gathered the information needed and how this article is organized. Part 2 discusses the definition of biothreat, biothreat agents, outbreaks of biothreat agents in the past and recent years, the implication of such outbreaks as well as why early detection is important. There was a bit difficulty in defining the meaning of biothreat because specific definition of the word is not easily available on the web even though it is very much commonly used (Google search on 24 June 2011 reveals 190,000 findings) Thus, I have made an attempt to define the word literally and using it in suitable context to achieve the purpose of this assignment. Pant 3 later discusses the definition of biosurveillance, the difference between biosurveillance and other existing type of surveillance i.e. public health surveillance and disease surveillance and the component of a biosurveillance system. Next in Part 4, I have detailed on methods of how to conduct a biosurveillance on biothreat agents which covers the methods of data collection, organizations involved, the data they collected, case detection and also eventually outbreak detection. In this part, I have also discussed the role of biosurveillance as tool for early detection of biothreat. Part S contains discussion on how to improve the current biosurveillance system and the future prospect of biosurveillance approach to detect early biothreat infection. Lastly Part 6 summarizes and concludes the information gathered and the discussions of the whole topic. I hope this article will benefit others who wished to understand the role of biosurveillance in early detection of biothreat.
  • Publication
    Common Variable Immunodeficiency (CVID)
    (Kuala Lumpur: Institute for Medical Research, 0011)
    Nisha Sabrina Aloysious
    Common Variable Immunodeficiency (CVID) is a disorder of primary immunodeficiency, characterized by low levels of serum immunoglobulins. This leads to an increased susceptibility to various infections, usually sinopulmonary ft is a relatively common form of primary immunodeficiency, second only to lg A deficiency. The prevalence of €VID is about 1/25 000 Caucasians ( The degree and type of deficiency of serum immunoglobulins in CVID, and the clinical course, varies from patient to patient, Patients with CVID may have normal levels of serum lgM levels but decreased serum levels of immunoglobulin G (lgG) and immunoglobulin A (lgA) are characteristic. Approximately 50% of patients with the deficiency may also have diminished T-lymphocyte dysfunction.
  • Publication
    Challenges in the Laboratory Diagnosis of Pandemic Influenza A (H1N1) 2009 in Developing Countries
    (Kuala Lumpur: Institute for Medical Research, 2011)
    Khalid Esmail Ali Bin Ali Mahaly
    In 2009, the world witnessed influenza pandemic, and the second of the two pandemics involving HIN influenza virus (the first of them was the 1918 flu pandemic), albeit in a new version. The pandemic spread quickly and affected many countries (Figure I). First described in April 2009, the virus appeared to be a new strain of HIN] which resulted when a previous triple reassortment of bird, swine and human flu viruses further combined with a Eurasian pig flu virus, leading to the term Swine flu" to be used for this pandemic. Unlike most strains of influenza, H1NI does not disproportionately infect adults older than 60 years; this was an unusual and characteristic feature of the H1NI pandemic Even in the case of previously very healthy persons, a small percentage will develop pneumonia or acute respiratory distress syndrome. This manifests itself as increased breathing difficulty and typically occurs 3-6 days after initial onset of flu symptoms.
  • Publication
    Describe the Surveillance System for One of the Most Important Infectious Disease in Your Country
    (Kuala Lumpur: Institute for Medical Research, 2011)
    Lee Pei Chen
    According World Health Organization (WHO) Global TB Control 2010 report, the stop TB Partnership Targets set for year 2015 and 2050 as below : i) 2015: Reduce prevalence and death rates by 50% compared with their levels in 1990. ii) 2050: Reduce the Global incidence of active TB cases to <1 case per 1 milion population / year
Most viewed
  • Publication
    Bacterial Fimbriae Structure and Function
    (Kuala Lumpur : Institute for Medical Research, 1986)
    R. Ardjuna M. Burhan
  • Publication
    The Medical Importance of Chlamydiae
    (Kuala Lumpur: Institute for Medical Research, 1984)
    Jerngklinchan, Jaowapa
    Chlamydias are obligatory intracellular parasites which were discovered b Halberstaedter and Prowazek in 1907. (Schachter, & Danson, 1979) At that time, it was discovered in producing the inclusion in the conjenctiva an d shortly thereater, the chlamydial infections of the human genital tract were recognized . At first, the chlamydiae, long considered to be viruses, have an uncertain taxonomic status. But they are now considered to belong to the family chlamydiaceae, which contain the genus chlamdiae. The organisms belonging to this genus are obligate procaryotis parasites that re[licate intraccellularly in eukaryocytes. All members of this genus undergo a complex develpomental cycle within the host cell cytoplasm and share a common antigen.
  • Publication
    Hybridoma Technology : Present Status
    (Kuala Lumpur: Institute for Medical Research, 1987)
    Cleto, Maria Cristina M.
  • Publication
    Occupational Infectious Diseases
    (Kuala Lumpur: Institute for Medical Research, 1983)
    Lertpatanasuwan, Anchalee
    Throughout the medieval period there was no contribution to the subject of occupational diseases, and it was not until the sixteenth century that definite information relating to diseases of miners and workmen in dangerous trades was found. It was in the middle of the sixteenth century that two remarkable men, Agricola and Paracelsus wrote on the subject of miners diseases. Agricola described in "De re Metallica" (Agricola, 1556) the diseases that prevailed in the mining community.Paracelsus based his monograph on occupational diseases of mine smelter workers (Paracelsus, 1567) on his experience as town physician in Villach, Australia.
  • Publication
    An Update on the Availability and Use of Aminoglycosides
    (Kuala Lumpur: Institute for Medical Research, 1984)
    Zara, Teresita M.
    It has been known for many years through experiments and observations that numerous microorganisms produce substances with the power to inhibit the multiplication of other microorganisms or even to kill them. Such subtances are known as antibitotics. Suprisingly, only 10% of the world production of antibiotics is put into proper usage. There should be a choice of antibiotics for testing and limitations, so as to avoid wastage and to discourage use of inappropriate antibiotics. For successful antimicrobial prophylaxis, up-date treatment using aminoglycosides have called for the attention of many clinicians and have adapted the use of aminoglycosides to provide efficient treatment to every patient.