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Statin intolerance: an updated, narrative review mainly focusing on muscle adverse effects

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dc.contributor.authorJian-Jun Li
dc.contributor.authorHui-Hui Liu
dc.contributor.authorNa-Qiong Wu
dc.contributor.authorKhung Keong Yeo
dc.contributor.authorKathryn Tan
dc.contributor.authorJunya Ako
dc.contributor.authorRungroj Krittayaphong
dc.contributor.authorRu San Tan
dc.contributor.authorPhilip E Aylward
dc.contributor.authorSang Hong Baek
dc.contributor.authorJamshed Dalal
dc.contributor.authorAlan Yean Yip Fong
dc.contributor.authorYi-Heng Li
dc.contributor.authorRichard C O’Brien
dc.contributor.authorTien Siang Eric Lim
dc.contributor.authorSi Ya Natalie Koh
dc.contributor.authorDaniel J Scherer
dc.contributor.authorHayato Tada
dc.contributor.authorVernon Kang
dc.contributor.authorJulie Butters
dc.contributor.authorStephen J Nicholls
dc.date.accessioned2024-08-25T06:47:09Z
dc.date.available2024-08-25T06:47:09Z
dc.date.issued2020
dc.description.abstractIntroduction: Statins have been established as the standard of care for dyslipidemia and preventing cardiovascular diseases while posing few safety concerns. However, misconceptions about statin intolerance lead to their underuse, indicating a need to improve the understanding of the safety of this treatment. Areas covered: We searched PubMed and reviewed literatures related to statin intolerance published between February 2015 and February 2020. Important large-scale or landmark studies published before 2015 were also cited as key evidence. Expert opinion: Optimal lowering of low-density lipoprotein cholesterol with statins substantially reduces the risk of cardiovascular events. Muscle adverse events (AEs) were the most frequently reported AEs by statin users in clinical practice, but they usually occurred at a similar rate with statins and placebo in randomized controlled trials and had a spurious causal relationship with statin treatment. We proposed a rigorous definition for identifying true statin intolerance and present the criteria for defining different forms of muscle AEs and an algorithm for their management. True statin intolerance is uncommon, and every effort should be made to exclude false statin intolerance and ensure optimal use of statins. For the management of statin intolerance, statin-based approaches should be prioritized over non-statin approaches.
dc.identifier.doi10.1080/17425255.2020.1802426
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/17425255.2020.1802426
dc.identifier.urihttps://repository.nih.gov.my/handle/123456789/1008
dc.language.isoen
dc.publisherTaylor & Francis Group
dc.relation.ispartofExpert Opinion on Drug Metabolism & Toxicology
dc.relation.journalExpert Opinion on Drug Metabolism & Toxicology
dc.titleStatin intolerance: an updated, narrative review mainly focusing on muscle adverse effects
dc.typejournal-article
dspace.entity.typePublication
oaire.citation.issue9
oaire.citation.volume16
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