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Seroprevalence of Hepatitis B Among Healthcare Workers in Asia and Africa and Its Association With Their Knowledge and Awareness: A Systematic Review and Meta-Analysis

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dc.contributor.authorNur Hasnah Maamor
dc.contributor.authorNor Asiah Muhamad
dc.contributor.authorNor Soleha Mohd Dali
dc.contributor.authorMohd Hatta Abdul Mutalip
dc.contributor.authorFatin Norhasny Leman
dc.contributor.authorTahir Aris
dc.contributor.authorNai Ming Lai
dc.contributor.authorMuhammad Radzi Abu Hassan
dc.date.accessioned2024-07-14T05:49:26Z
dc.date.available2024-07-14T05:49:26Z
dc.date.issued2022
dc.description.abstractThe hepatitis B virus (HBV) is a blood-borne virus that can be transmitted by percutaneous and mucocutaneous contact with infected bodily fluid. Healthcare workers (HCWs) are more exposed to HBV infection. They must have a thorough understanding of HBV infection since they can contract and spread the virus. In this study, we systematically reviewed all published evidence on the seroprevalence of Hepatitis B virus (HBV) infection among HCWs. and synthesize evidence on the association between knowledge and awareness with HBV infection. <jats:title>Methods</jats:title><jats:p>We searched PubMed, EMBASE, Cochrane Library and Scopus for studies reporting on HBV seroprevalence from January 1997 to September 2021 among healthcare workers. We used random-effects meta-analyses to estimate the pool prevalence of HBV infection.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We identified 25 studies that met our inclusion criteria, with data on 10,043 adults from 11 countries and two regions: Africa and Asia. The overall seroprevalence of HBV was 5.0% (95% confidence interval [CI] 3.6%), with Africa reporting higher estimates (5.0%, 95% CI 3.7%) than Asia population (4.0%, 95% CI 1.9%). The highest pooled prevalence estimate in African countries came from studies published in the Cameroon region (8.0%, 95% CI 5–10%) while the lowest came from Ethiopia (4.0%, 95% CI 2.6%). The overall seroprevalence estimates in the African population were significantly higher than those in the Asian group. Studies in Africa found that the average knowledge and seroprevalence were 1.4% and 11.0%, respectively where, eight studies (53.3%) reported good knowledge and seven studies (46.7%) reported average knowledge. In Asia, two studies (40.0%) reported good knowledge, one study (20.0%) reporting average knowledge, and two studies (40.0%) reporting poor knowledge. African studies demonstrated good knowledge despite the fact that their HBV infection rate was higher than 6.7%.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Africa and Asia have the highest seroprevalence of HBV infection. Improving the comparability of epidemiological and clinical studies constitutes an important step forward. More high-quality data is needed to improve the precision of burden estimates.</jats:p></jats:sec><jats:sec><jats:title>Systematic Review Registration</jats:title><jats:p>PROSPERO CRD42021279905.</jats:p></jats:sec>
dc.identifier.doi10.3389/fpubh.2022.859350
dc.identifier.urihttps://repository.nih.gov.my/handle/123456789/518
dc.relation.ispartofFrontiers in Public Health
dc.relation.issn2296-2565
dc.titleSeroprevalence of Hepatitis B Among Healthcare Workers in Asia and Africa and Its Association With Their Knowledge and Awareness: A Systematic Review and Meta-Analysis
dc.typejournal-article
dspace.entity.typePublication
oaire.citation.volume10
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