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Comorbidities and clinical features related to severe outcomes among COVID-19 cases in Selangor, Malaysia

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dc.contributor.authorWan Shakira Rodzlan Hasani
dc.contributor.authorShubash Shander Ganapathy
dc.contributor.authorChong Zhuo Lin
dc.contributor.authorHalizah Mat Rifin
dc.contributor.authorMohammad Nazaruddin Bahari
dc.contributor.authorMuhammad Haikal Ghazali
dc.contributor.authorNoor Aliza Lodz
dc.contributor.authorMuhammad Hafizuddin Taufik Ramli
dc.contributor.authorNur Liana Ab Majid
dc.contributor.authorJane Ling Miaw Yn
dc.contributor.authorMuhammad Fadhli Mohd Yusoff
dc.contributor.authorNoor Ani Ahmad
dc.contributor.authorAnita Suleiman
dc.contributor.authorAhmad Faudzi Yusoff
dc.contributor.authorVenugopalan Balan
dc.contributor.authorSha'ari Ngadiman
dc.date.accessioned2024-07-18T03:16:23Z
dc.date.available2024-07-18T03:16:23Z
dc.date.issued2021
dc.description.abstractBackground: Pre-existing comorbidities are predictive of severe COVID-19 infection requiring intubation and mechanical ventilation. This study determined comorbidity and additional predictive factors for invasive ventilatory support among Malaysian COVID-19 patients. Method: Field data collected during COVID-19 outbreak in Selangor, Malaysia up to 13th April 2020 were used. It contained sociodemographic characteristics, comorbidities, and presenting symptoms of COVID-19 cases. Their medical records were traced for information on intensive care unit admission requiring intubation and mechanical ventilation. Results: A total of 1,287 COVID-19 positive cases were included in the analysis. The most common comorbidities among COVID-19 patients were hypertension (15.5%) and diabetes (11.0%). More than one third of symptomatic patients presented with fever (43.8) and cough (37.1%). Among all 25 intubated cases, 68.0% had hypertension, 88.0% had fever, 40.0% had dyspnoea and 44.0% was lethargic. Multivariable regression model showed that the odds of being intubated among COVID-19 patients were significantly higher among older person (aged ?60 years) [adjusted odd ratio (aOR=3.9)], those who had hypertension (aOR =5.7), presented with fever (aOR=9.8), dyspnoea (aOR=9.6), and lethargy (aOR = 7.9). Conclusion: Old age, hypertension, and several presenting symptoms were strong risk factors for invasive ventilatory support among COVID-19 patients. They must be diagnosed early and monitored closely to improve clinical outcome.
dc.identifier.doi10.5365/wpsar.2020.11.3.007
dc.identifier.urihttps://repository.nih.gov.my/handle/123456789/608
dc.relation.ispartofWestern Pacific Surveillance and Response Journal
dc.titleComorbidities and clinical features related to severe outcomes among COVID-19 cases in Selangor, Malaysia
dc.typejournal-article
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume12
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