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Elevated levels of IL-8 in fatal leptospirosis

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dc.contributor.authorWan Shahriman Yushdie Wan Yusoff
dc.contributor.authorMaha Abdullah
dc.contributor.authorZamberi Sekawi
dc.contributor.authorFairuz Amran
dc.contributor.authorMuhammad Yazli Yuhana
dc.contributor.authorNiazlin Mohd Taib
dc.contributor.authorAnim Md. Shah
dc.contributor.authorSyafinaz Amin Nordin
dc.date.accessioned2024-08-25T06:52:18Z
dc.date.available2024-08-25T06:52:18Z
dc.date.issued2020
dc.description.abstractLeptospirosis causes a wide range of clinical outcomes, including organ failure and death. Earlytreatment significantly increases the chances of cure. Interleukin-8 (IL-8) is a chemoattractant cytokine for neutrophil and is associated with multiple organ failure. Research has indicated IL 8 to be raised in severe and fatal cases of leptospirosis, but its suitability as a prognostic biomarker has yet to be confirmed. This study aimed to evaluate the significance of IL-8 with the clinical outcomes of leptospirosis patients. Plasma IL-8 was measured in fifty-two samples from hospitalized patients and nineteen healthy controls. The comparisons were made between mild, severe-survived and fatal groups identified by clinical or laboratory findings. IL-8 was significantly higher in fatal (p = 0.01) compared to mild cases. IL-8 was also significantly higher in fatal (p = 0.02) when compared to survived cases of leptospirosis. IL-8 levels in the plasma of fatal leptospirosis cases were significantly elevated compared to survived cases and may serve as a potential prognostic biomarker in determining the possible outcome of leptospirosis patients.
dc.identifier.doi10.1080/20477724.2020.1724356
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/32024441/
dc.identifier.urihttps://repository.nih.gov.my/handle/123456789/1011
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.ispartofPathogens and Global Health
dc.relation.issn2047-7724
dc.relation.journalPATHOGENS AND GLOBAL HEALTH
dc.subjectIL-8
dc.subjectCytokines
dc.subjectLeptospirosis
dc.subjectClinical Outcomes
dc.subjectMalaysia
dc.titleElevated levels of IL-8 in fatal leptospirosis
dc.typejournal-article
dspace.entity.typePublication
oaire.citation.issue2
oaire.citation.volume114
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