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Diagnostic accuracy of Cardiochek® PA point-of-care testing (POCT) analyser with a 3-in-1 lipid panel for epidemiological surveys

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dc.contributor.authorTania Gayle Robert Lourdes
dc.contributor.authorZhuo Lin Chong
dc.contributor.authorThamil Arasu Saminathan
dc.contributor.authorHamizatul Akmal Abd Hamid
dc.contributor.authorHalizah Mat Rifin
dc.contributor.authorKim Sui Wan
dc.contributor.authorNur Liana Ab Majid
dc.contributor.authorKishwen Kanna Yoga Ratnam
dc.contributor.authorMohd Ruhaizie Riyadzi
dc.contributor.authorHasimah Ismail
dc.contributor.authorNazirah Alias
dc.contributor.authorMuhammad Fadhli Mohd Yusoff
dc.date.accessioned2025-01-14T05:07:19Z
dc.date.available2025-01-14T05:07:19Z
dc.date.issued2024
dc.description.abstractBackground: Point-of-care testing (POCT) is commonly used in epidemiological surveys due to its various advantages, such as portability and immediate test results. The CardioChek® PA analyser 3-in-1 lipid panel measures total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol. This study tested the reliability and diagnostic accuracy of the CardioChek® PA analyser using a 3-in-1 lipid panel. Methods: A cross-sectional study design with quota sampling was used. A total of 203 respondents aged 18 years and above from a research centre in the Ministry of Health, Malaysia, were recruited. Venous blood was sent to the laboratory and tested with Siemens Atellica CH, while a POCT analyser was used for capillary blood measurements. Intraclass coefficient correlation (ICC) analysis was employed to determine the agreement between capillary and venous blood parameters. The diagnostic performance of the evaluated tests was evaluated using STATA version 12. Results: The agreement between capillary and laboratory venous blood was moderate (0.64–0.67) for TC and HDL, good (0.75) for LDL and excellent (0.91) for TG). The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were as follows: TC, 57.1%, 94.3%, 92.3% and 64.8%; TG, 76.0%, 100%, 100%, and 96.6%; HDL, 96.2%, 83.2%, 47.2% and 99.3%; and LDL, 81.0%, 100%, 100% and 68.3%, respectively. Conclusions: The CardioChek® PA analyser showed acceptable diagnostic accuracy for screening high-risk individuals more often in places where laboratories are inaccessible. It could also be used in clinical settings where patients would benefit from swift treatment decisions.
dc.identifier.doihttps://doi.org/10.1186/s12944-024-02270-2
dc.identifier.urihttps://repository.nih.gov.my/handle/123456789/1343
dc.language.isoen
dc.relation.ispartofLipids in Health and Disease
dc.relation.journalHealth and Disease
dc.subjectEpidemiological survey
dc.subjectCardioChek® PA
dc.subjectPoint-of-care testing (POCT)
dc.subjectDiagnostic accuracy
dc.subjectCholesterol
dc.subjectLipid
dc.titleDiagnostic accuracy of Cardiochek® PA point-of-care testing (POCT) analyser with a 3-in-1 lipid panel for epidemiological surveys
dc.typejournal-article
dspace.entity.typePublication
oaire.citation.startPage23
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