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Molecular characterization of influenza A (H7N9) virus from the first imported H7N9 infection case in Malaysia

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dc.contributor.authorS. Jeyanthi
dc.contributor.authorRogayah T. A. R. Tengku
dc.contributor.authorR. Thayan
dc.contributor.authorA. Az-UlHusna
dc.contributor.authorA. Aruna
dc.contributor.authorB. V. Khebir
dc.contributor.authorB. Thevarajah
dc.contributor.authorS. Maria
dc.contributor.authorS. Zainah
dc.date.accessioned2024-12-20T09:56:39Z
dc.date.available2024-12-20T09:56:39Z
dc.date.issued2014
dc.description.abstractH7N9 is an avian strain of the species Influenza virus that circulates among avian populations. Occasionally, some variants of this strain were known to infect humans. On March 30, 2013, a novel avian influenza A H7N9 virus that infects human beings was identified in China. In February 2014, the first case of H7N9 infection outside China was reported in Malaysia involving a Chinese tourist. This study was aimed to characterize the first case of H7N9 in Malaysia by means of molecular identification, sequencing of hemagglutinin (HA) and neuraminidase (NA) genes, and phylogenetic analysis. The patient was confirmed positive for H7N9 virus by real-time RT-PCR (rRT-PCR). Subsequently, the samples were sequenced and mutation analysis identified R65K, E122K, L186I and N285D mutations in HA gene and M26I, R78K and V345I mutations in NA gene. We reported the emergence of a new mutation L186I, not found in the current database of any H7N9 sequences. Mutations associated with drug resistance were not found in this patient. Phylogenetic analysis revealed that the HA gene is closely related to the group of strains from Guangzhou, whereas NA gene is closely related to the group of strains from Guangdong. The present study provides crucial information on the first case of H7N9 outside China and the diversity of this strain from other reported H7N9 strains by molecular analysis.
dc.identifier.doihttps://doi.org/10.5897/JGMV2014.0057
dc.identifier.urihttps://repository.nih.gov.my/handle/123456789/1260
dc.publisherJournal of General and Molecular Virology
dc.relation.ispartofJournal of General and Molecular Virology
dc.relation.issn2141-6648
dc.subjectH7N9
dc.subjectavian strain
dc.subjectChina
dc.subjectmolecular analysis
dc.subjectinfluenza virus
dc.titleMolecular characterization of influenza A (H7N9) virus from the first imported H7N9 infection case in Malaysia
dc.typejournal-article
dspace.entity.typePublication
oaire.citation.issue2
oaire.citation.volume6
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