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Etiologies of tropical acute febrile illness in West Pahang, Malaysia: A prospective observational study

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dc.contributor.authorMohdHatta Abdul Mutalip
dc.contributor.authorAlifAdlan Mohd Thabit
dc.contributor.authorWan MohdRasis Wan Ahmad Kamil
dc.contributor.authorMohdRamadhan Mohd Din
dc.contributor.authorMohan Arumugam
dc.contributor.authorSitiSanaa Wan Azman
dc.contributor.authorRoslinda Jaafar
dc.contributor.authorSathvinderSingh Gian Singh
dc.contributor.authorRafidah Abdullah
dc.contributor.authorEidaNurhadzira Muhammad
dc.contributor.authorNorAsiah Muhamad
dc.date.accessioned2024-07-18T05:05:43Z
dc.date.available2024-07-18T05:05:43Z
dc.date.issued2020-03
dc.description.abstractObjective: To determine the etiologies of tropical acute febrile illness (TAFI) in West Pahang, Malaysia and to investigate morbidity and mortality factors in relation to TAFI. Methods: A multicenter prospective cohort study was conducted between January and June 2016 in six district hospitals throughout the western part of Pahang State in Peninsular Malaysia. A total of 336 patients answered a standardized questionnaire and blood samples were collected for laboratory confirmation of infectious etiology. Descriptive analysis and logistic regression were performed to identify factors associated with TAFI. Results: A total of 336 patients were included. The patients were mainly Malays (70.2%), males (61.3%), aged (44.6±17.4) years, with more than half (58.9%) presenting with gastrointestinal symptoms. The majority were diagnosed with dengue (35.7%) while malaria (4.5%) was the least frequent. The in-hospital mortality due to TAFI was 9.2%. Patients with meliodosis had five times higher mortality [Adjusted OR: 5.002, 95% CI: (1.233, 20.286)]. Patients with comorbidities such as cardiovascular symptoms (P<0.001) and renal replacement therapy initiation (P<0.001) were significantly associated with in-hospital mortality in all TAFI. Conclusions: The etiology of TAFI in the western Pahang includes dengue, leptospirosis, malaria and melioidosis, which carry the highest risk of in-hospital mortality. The presence of cardiovascular symptoms may be used to assess the disease severity in TAFI, but more studies are needed in the future.
dc.identifier.doi10.4103/1995-7645.278096
dc.identifier.urihttps://journals.lww.com/aptm/fulltext/2020/13030/etiologies_of_tropical_acute_febrile_illness_in.4.aspx#:~:text=The%20etiology%20of%20TAFI%20in%20the%20western%20part%20of%20Pahang,and%20malaria%20were%20the%20least.
dc.identifier.urihttps://repository.nih.gov.my/handle/123456789/616
dc.language.isoen
dc.publisherWolter Kluwer Medknow Publications
dc.relation.ispartofAsian Pacific Journal of Tropical Medicine
dc.relation.issn1995-7645
dc.relation.journalAsian Pacific Journal of Tropical Medicine
dc.subjectTAFI
dc.subject: Comorbidities
dc.subjectMortality
dc.subjectTropical acute febrile illness
dc.titleEtiologies of tropical acute febrile illness in West Pahang, Malaysia: A prospective observational study
dc.typejournal-article
dspace.entity.typePublication
oaire.citation.issue3
oaire.citation.volume13
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