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Modelling the prognostic effect of glucose and lipid profiles on stroke recurrence in Malaysia: an event-history analysis

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dc.contributor.authorXin Wee Chen
dc.contributor.authorMohd Nazri Shafei
dc.contributor.authorZariah Abdul Aziz
dc.contributor.authorNorsima Nazifah Sidek
dc.contributor.authorKamarul Imran Musa
dc.date.accessioned2024-09-09T07:16:28Z
dc.date.available2024-09-09T07:16:28Z
dc.date.issued2020
dc.description.abstractBackground: Diabetes and dyslipidemia are significantly associated with stroke recurrence, yet the evidence for this relationship is conflicting. Consequently, the parameters in the glucose and lipid profiles may inform us regarding their relationship with stroke recurrence, thus enhancing the physicians’ clinical decision-making. Aim. This study sought to investigate whether glucose and lipid profiles could prognosticate stroke recurrence in Malaysia. Methods: We conducted a retrospective hospital-based study where we analyzed the first-ever stroke cases regarding about which the Malaysia National Stroke Registry was informed between 2009 and 2017, that fulfilled this study’s criteria, and that were followed for stroke recurrence. Using the Cox proportional hazard regression analysis, we estimated the adjusted hazard ratios (HRs), which reflected the prognostic effect of the primary variables (i.e., glucose and lipid profiles on the first-stroke admission) on stroke recurrence. Results: Among the 8,576 first-ever stroke patients, 394 (4.6%) experienced a subsequent first stroke recurrence event. The prognostic effect measured by univariable Cox regression showed that, when unadjusted, ten variables have prognostic value with regards to stroke recurrence. A multivariable regression analysis revealed that glucose was not a significant prognostic factor (adjusted HR 1.28; 95% CI [1.00–1.65]), while triglyceride level was the only parameter in the lipid profile found to have an independent prognostication concerning stroke recurrence (adjusted HR: 1.28 to 1.36). Conclusions: Triglyceride could independently prognosticate stroke recurrence, which suggests the role of physicians in intervening hypertriglyceridemia. In line with previous recommendations, we call for further investigations in first-ever stroke patients with impaired glucose and lipid profiles and suggest a need for interventions in these patients.
dc.identifier.doi10.7717/peerj.8378
dc.identifier.urihttps://peerj.com/articles/8378/
dc.identifier.urihttps://repository.nih.gov.my/handle/123456789/1078
dc.language.isoen
dc.relation.ispartofPeerJ
dc.relation.issn2167-8359
dc.subjectDiabetes and Endocrinology
dc.subjectEpidemiology
dc.subjectInternal Medicine
dc.subjectNeurology
dc.subjectPublic Health
dc.titleModelling the prognostic effect of glucose and lipid profiles on stroke recurrence in Malaysia: an event-history analysis
dc.typejournal-article
dspace.entity.typePublication
oaire.citation.volume8
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