In Vitro Study to determine the effect of zinc on non-heme iron absorption

Publication:
In Vitro Study to determine the effect of zinc on non-heme iron absorption

dc.date.accessioned	2025-03-13T04:54:57Z
dc.date.available	2025-03-13T04:54:57Z
dc.date.issued	2011
dc.description.abstract	It has been well documented that bioavailability of iron is influenced by other food constituents. We carried out a kinetic study to look at the effect of zinc on ferric iron uptake in human epithelial Caco-2 TC7 cell-line. Zinc reduced iron uptake in a concentration-dependent manner. Iron uptake was significantly increased in the presence of ascorbic acid in the medium. We also found that zinc significantly increased the main iron transporter Divalent Metal Transporter-1 (DMT1) expression in whole cell and membrane proteins. The evidence from in vitro studies show that zinc suppressed iron uptake by Caco-2 cells and this phenomenon could be reversed by the presence of ascorbic acid in the growth media.
dc.identifier.uri	https://repository.nih.gov.my/handle/123456789/1542
dc.language.iso	en
dc.relation.journal	International Journal of Collaborative Research on Internal Medicine & Public Health
dc.subject	Iron uptake
dc.subject	Caco-2 TC& cells
dc.subject	Zinc
dc.subject	Ascorbic acid
dc.subject	Ferric iron
dc.title	In Vitro Study to determine the effect of zinc on non-heme iron absorption
dc.type	text::journal::journal article
dspace.entity.type	Publication
oaire.citation.endPage	368
oaire.citation.issue	5
oaire.citation.startPage	354
oaire.citation.volume	3