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Piper sarmentosum is comparable to glycyrrhizic acid in reducing visceral fat deposition in adrenalectomised rats given dexamethasone

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dc.contributor.authorA Fairus
dc.contributor.authorS Ima Nirwana
dc.contributor.authorMR Elvy Suhana
dc.contributor.authorMH Tan
dc.contributor.authorR Santhana
dc.contributor.authorHS Farihah
dc.date.accessioned2025-03-12T03:36:16Z
dc.date.available2025-03-12T03:36:16Z
dc.date.issued2013
dc.description.abstractObjectives. Visceral obesity may be due to the dysregulation of cortisol production or metabolism that lead to metabolic disease. In adipose tissue, the enzyme 11β-hydroxysteroid dehydrogenase type 1 regulates cortisol metabolism (11β-HSD1). A previous study showed an increase in the visceral fat deposition in adrenalectomised rats given intramuscular dexamethasone. Glycyrrhizic acid (GCA) has been shown to reduce fat deposition because it is a known potent inhibitor of the 11β-HSD1 enzyme. Piper sarmentosum (PS) is an edible medicinal plant commonly used in Asia as traditional medicine for treating diabetes, hypertension and joint pains. In this study, we determined the effects of PS extract on the disposition and morphology of perirenal adipocytes of adrenalectomised rats given intramuscular dexamethasone. Materials and Methods. A total of 21 male Spraque Dawley rats were adrenalectomised and given intramuscular dexamethasone, 120 μg/kg/day. These rats were further divided into three groups: adrenalectomised control (ADR+Dexa; n=7), GCA-treated (ADR+Dexa+GCA; dose=240 mg/kg/day; n=7) and PS-treated (ADR+Dexa+PS; dose=125 mg/kg/day; n=7) groups. The various treatments were given via gastric gavage following 2 weeks of adrenalectomy. Results. Treatment with PS extract for 8 weeks showed decreased deposition of perirenal adipocytes which was similar to the GCA-treated group. However, PS-treated rats had thinner adipocyte membrane compared with that of the GCA-treated group. Conclusion. In conclusion, PS extract decreased perirenal fat deposition and reduced the diameter of the adipocyte membrane. However, the mechanisms of action needed further study
dc.identifier.doi10.7417/CT.2013.1502
dc.identifier.urihttps://repository.nih.gov.my/handle/123456789/1531
dc.language.isoen
dc.relation.journalLa Clinica terapeutica
dc.subjectadipocyte size
dc.subjectadrenalectomised rat
dc.subjecthyperplasia
dc.subjectperirenal fat
dc.subjectpiper sarmentosum
dc.titlePiper sarmentosum is comparable to glycyrrhizic acid in reducing visceral fat deposition in adrenalectomised rats given dexamethasone
dc.typetext::journal::journal article
dspace.entity.typePublication
oaire.citation.endPage10
oaire.citation.issue1
oaire.citation.startPage5
oaire.citation.volume164
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