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Seroprevalence of hepatitis B virus and hepatitis C virus infection among Malaysian population

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dc.contributor.authorNor Asiah Muhamad
dc.contributor.authorRimah Melati Ab.Ghani
dc.contributor.authorMohd Hatta Abdul Mutalip
dc.contributor.authorEida Nurhadzira Muhammad
dc.contributor.authorHasmah Mohamad Haris
dc.contributor.authorRozainanee Mohd Zain
dc.contributor.authorNoraidatulakma Abdullah
dc.contributor.authorNor Azila Muhammad Azami
dc.contributor.authorNazihah Abd Jalal
dc.contributor.authorNorliza Ismail
dc.contributor.authorNurul Ain Mhd Yusuf
dc.contributor.authorRaihannah Othman
dc.contributor.authorAzwa Shawani Kamalul Arifin
dc.contributor.authorMohd Shaharom Abdullah
dc.contributor.authorMohd Arman Kamaruddin
dc.contributor.authorMuhammad Radzi Abu Hassan
dc.contributor.authorTahir Aris
dc.contributor.authorRahman Jamal
dc.date.accessioned2024-07-26T02:28:05Z
dc.date.available2024-07-26T02:28:05Z
dc.date.issued2020
dc.description.abstractMalaysia is a country with an intermediate endemicity for hepatitis B. As the country moves toward hepatitis B and C elimination, population-based estimates are necessary to understand the burden of hepatitis B and C for evidence-based policy-making. Hence, this study aims to estimate the prevalence of hepatitis B and C in Malaysia. A total of 1458 participants were randomly selected from The Malaysian Cohort (TMC) aged 35 to 70 years between 2006 and 2012. All blood samples were tested for hepatitis B and C markers including hepatitis B surface antigen (HBsAg), anti-hepatitis B core antibody (anti-HBc), antibodies against hepatitis C virus (anti-HCV). Those reactive for hepatitis C were further tested for HCV RNA genotyping. The sociodemographic characteristics and comorbidities were used to evaluate their associated risk factors. Descriptive analysis and multivariable analysis were done using Stata 14. From the samples tested, 4% were positive for HBsAg (95% CI 2.7–4.7), 20% were positive for anti-HBc (95% CI 17.6–21.9) and 0.3% were positive for anti-HCV (95% CI 0.1–0.7). Two of the five participants who were reactive for anti-HCV had the HCV genotype 1a and 3a. The seroprevalence of HBV and HCV infection in Malaysia is low and intermediate, respectively. This population-based study could facilitate the planning and evaluation of the hepatitis B and C control program in Malaysia.
dc.identifier.doihttps://doi.org/10.1038/s41598-020-77813-5
dc.identifier.urihttps://repository.nih.gov.my/handle/123456789/714
dc.language.isoen
dc.relation.ispartofScientific Reports
dc.relation.issn2045-2322
dc.titleSeroprevalence of hepatitis B virus and hepatitis C virus infection among Malaysian population
dc.typejournal-article
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume10
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