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Incidence, Clinico-demographic Profiles and Survival Rates of Colorectal Cancer in Northern Malaysia: Comparing Patients Above and Below 50 Years of Age

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dc.contributor.authorNik Razima Wan Ibrahim
dc.contributor.authorHuan-Keat Chan
dc.contributor.authorShahrul Aiman Soelar
dc.contributor.authorAhmad Najib Azmi
dc.contributor.authorRosaida Mohd Said
dc.contributor.authorMuhammad Radzi Abu Hassan
dc.date.accessioned2024-07-30T07:47:05Z
dc.date.available2024-07-30T07:47:05Z
dc.date.issued2020
dc.description.abstractBackground: While the world witnesses an increasing trend of young-onset colorectal cancer (CRC), the information regarding the impact of age on CRC is limited in Malaysia. This study aimed to compare the incidence, clinic-demographic profiles and survival rates of CRC between patients above and under 50 years of age in northern Malaysia. Methods: This was a registry-based, cross-sectional study. All the CRC cases reported by 18 hospitals to the National Cancer Patient Registry - Colorectal Cancer (NCPR-CC) between January 2007 and December 2017 were included in the analysis. The patients were categorized by age into the above-50 and under-50 groups. The changes in the age-standardized incidence and mortality rates of both the age groups were determined using the time-series analysis, and the impact of age on the mortality risk was assessed using the Cox regression analysis. Results: Of the 6,172 CRC patients enrolled in the NCPR-CC, 893 (14.5%) were in the under-50 group. As compared with their older counterparts, the patients in the under-50 group were more likely to be female, be of Malay ethnicity, be non-smokers, have a family history of CRC, and present late for treatment. The age-standardized incidence and mortality rates of CRC in the under-50 group remained stable over the years, while a decreasing trend was clearly seen in the mortality rates of CRC in the above-50 group (p=0.003). Nevertheless, the two age groups also did not differ in the mortality risk (adjusted hazards ratio: 1.10; 95% CI: 0.90, 1.36). Conclusion: Young-onset CRC constituted a considerable proportion of CRC cases in Malaysia. However, in contrast with the findings of most studies, it demonstrated neither an uptrend in age-standardized incidence rates nor a higher mortality risk. Our findings suggest the need to upscale and lower the recommended age for CRC screening in Malaysia.
dc.identifier.doi10.31557/APJCP.2020.21.4.1057
dc.identifier.urihttps://journal.waocp.org/article_89033.html
dc.identifier.urihttps://repository.nih.gov.my/handle/123456789/750
dc.language.isoen
dc.publisherAsian Pacific Organization for Center Prevention
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.relation.issn2476-762X
dc.relation.journalAsian Pacific Journal of Cancer Prevention
dc.subjectcolorectal neoplasms
dc.subjectearly detection of cancer
dc.subjectMalaysia
dc.subjectsurvival rate
dc.subjectEpidemiology general
dc.titleIncidence, Clinico-demographic Profiles and Survival Rates of Colorectal Cancer in Northern Malaysia: Comparing Patients Above and Below 50 Years of Age
dc.typejournal-article
dspace.entity.typePublication
oaire.citation.issue4
oaire.citation.volume21
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