Common Variable Immunodeficiency (CVID) is a disorder of primary immunodeficiency, characterized by low levels of serum immunoglobulins. This leads to an increased susceptibility to various infections, usually sinopulmonary ft is a relatively common form of primary immunodeficiency, second only to lg A deficiency. The prevalence of €VID is about 1/25 000 Caucasians ( The degree and type of deficiency of serum immunoglobulins in CVID, and the clinical course, varies from patient to patient, Patients with CVID may have normal levels of serum lgM levels but decreased serum levels of immunoglobulin G (lgG) and immunoglobulin A (lgA) are characteristic. Approximately 50% of patients with the deficiency may also have diminished T-lymphocyte dysfunction.

According World Health Organization (WHO) Global TB Control 2010 report, the stop TB Partnership Targets set for year 2015 and 2050 as below : i) 2015: Reduce prevalence and death rates by 50% compared with their levels in 1990. ii) 2050: Reduce the Global incidence of active TB cases to <1 case per 1 milion population / year

Hepatitis B virus (HBV) infection is a global health problem and the clinical outcome of chronic HBV infection depends on the frequency and severity of hepatitis flares in the immune clearance phase. At present, thirty four subgenotypes and ten genotypes (A-J) of HBV are identified and most have specific geographic distributions. The impact of these HBV genotypes on the clinical outcome of chronic HBV infection needs to be further clarified.