Browsing by Author "Wan-Fei Khaw"
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- PublicationEstimating the COVID-19 mortality burden over two full years of the pandemic in Malaysia(2022)
;LeeAnn Tan ;Shubash Shander Ganapathy ;Yee Mang Chan ;Nazirah Alias ;Nur Hamizah Nasaruddin ;Wan-Fei KhawAzahadi OmarMalaysia reported its first known local transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on 5 February 2020.1 On 17 March 2020, the first two deaths from coronavirus disease 2019 (COVID-19) in the country occurred—just a week after the World Health Organization (WHO) formally declared the growing outbreak a pandemic. Two years into the current pandemic, there have been over 32,000 deaths linked to COVID-19 in Malaysia over three major epidemic waves and a cumulative case count of over three million, making it one of the most affected countries in the Western Pacific region. Absolute death counts are often the metric of choice in official reports (and in accompanying graphics—often in large, bold numbers—circulated through social media or chat groups to be fixated upon by the populace) summaris ing the latest COVID-19 statistics. Burden of disease approaches, such as measuring years of life lost (YLL) owing to premature death from a disease, offer a more appropriate metric than number of deaths for measuring the mortality burden of a disease on a population and sub-populations by recognising that deaths at youn ger ages have a greater impact on population health. This study aims to estimate the burden of mortality from COVID-19 by calculating YLL to COVID-19 over two full years of the pandemic in Malaysia, to compare YLL rates across different states, and to compare the impact of mortality directly attributable to COVID-19 relative to deaths from other leading causes of disease and injury in the country in pre-pandemic times. - PublicationFactors influencing the prevalence of cervical cancer screening in Malaysia: a nationwide survey(2023)
;Yee Mang Chan ;Muhd Zulfadli Hafiz IsmailWan-Fei KhawBackground: In 2020, cervical cancer ranked fourth in terms of both frequency of diagnosis and the leading cause of cancer-related deaths among women globally. Among Malaysian women, it was the third most prevalent form of cancer. Published data on nationally representative cervical cancer screening in Malaysia have been limited. Therefore, this study aimed to determine the prevalence of receiving a Pap smear test in the past three years, its relationship with socio-demographic factors and physical activity. Methods: Using a subset of survey data from the National Health and Morbidity Survey (NHMS) 2019, a secondary data analysis was performed. Trained research assistants collected data through face-to-face method using a mobile tablet questionnaire system application. Logistic regression analysis was performed to examine the relationship between sociodemographic factors, physical activity, and cervical cancer screening. The analyses were conducted using STATA version 14 (Stata Corp, College Station, Texas, USA), accounting for sample weighs and complex sampling design. Results: The analysis included 5,650 female respondents, representing an estimated 10.3 million Malaysian female adults aged 18 and above. Overall, 35.2% (95%CI 33.2, 37.4) respondents had a Pap smear test within the past three years. Respondents who were physically active were 1.41 times more likely to have a Pap smear test. Similarly, respondents aged 35–59 (OR 1.84; 95%CI 1.46, 2.34) and those living in rural localities (OR 1.38; 95%CI 1.13, 1.70) had higher odds of receiving a Pap smear test. Compared to married respondents, single respondents (OR 0.04; 95%CI 0.02, 0.07) and widowed/divorcee respondents (OR 0.72; 95%CI 0.56, 0.82) were less likely to receive a Pap smear test. Educated respondents were more likely to have had a Pap smear test. Conclusions: The overall prevalence of cervical cancer screening in Malaysia remains low (35.2%). Efforts should be made to strengthen health promotion programs and policies in increasing awareness on the significance of cervical cancer screening. These initiatives should specifically target younger women, single women, and widowed/divorced individuals. The higher cervical screening uptake among rural women should be studied further, and the enabling factors in the rural setup should be emulated in urban areas whenever possible. - PublicationMalaysian burden of disease: years of life lost due to premature deaths(2023)
;Wan-Fei Khaw ;Yee Mang Chan ;Nur Hamizah Nasaruddin ;Nazirah Alias ;LeeAnn TanShubash Shander GanapathyBackground: In Malaysia, the previous mortality burden has been a significant concern, particularly due to the high prevalence of noncommunicable diseases (NCDs) as the leading cause of death. Estimates of mortality are key indicators for monitoring population health and determining priorities in health policies and health planning. The aim of this study was to estimate the disease burden attributed to 113 major diseases and injuries in Malaysia in 2018 using years of life lost (YLL) method. Methods: This study included all deaths that occurred in Malaysia in 2018. The YLL was derived by adding the number of deaths from 113 specific diseases and multiplying it by the remaining life expectancy for that age and sex group. Data on life expectancy and mortality were collected from the Department of Statistics Malaysia. Results: In 2018, there were 3.5 million YLL in Malaysia. Group II (NCDs) caused 72.2% of total YLL. Ischaemic heart disease was the leading cause of premature mortality among Malaysians (17.7%), followed by lower respiratory infections (9.7%), road traffic injuries (8.7%), cerebrovascular disease (stroke) (8.0%), and diabetes mellitus (3.9%). Conclusions: NCDs are a significant health concern in Malaysia and are the primary contributor to the overall burden of disease. These results are important in guiding the national health systems on how to design and implement effective interventions for NCDs, as well as how to prioritise and allocate healthcare resources. Key strategies to consider include implementing health promotion campaigns, adopting integrated care models, and implementing policy and regulatory measures. These approaches aim to enhance health outcomes and the managements of NCDs in Malaysia. - PublicationSocio‑demographic factors and healthy lifestyle behaviours among Malaysian adults: National Health and Morbidity Survey 2019(Nature Portfolio, 2022-10-04)
;Wan-Fei Khaw ;Nur Hamizah Nasaruddin ;Nazirah Alias ;Yee Mang Chan ;LeeAnn Tan ;Siew Man Cheong ;Shubash Shander Ganapathy ;Muhammad Fadhli Mohd YusoffHeng Yaw YongThis study aimed to investigate the association between socio-demographic factors and designated healthy lifestyle behaviours in a nationally-representative sample of Malaysian adults aged 18 years and above. Secondary data involving 7388 participants aged 18–96 years from the National Health and Morbidity Survey 2019, a national cross-sectional survey, was used in this study. A healthy lifestyle score (0–5 points) was calculated based on five modifiable lifestyle factors: non-smoker, body mass index < 25 kg/m2, physically active, moderate (or less) alcohol intake, and daily consumption of ≥ 5 servings of fruits and vegetables. Associations between socio-demographic factors and healthy lifestyle behaviours were examined using multinomial logistic regression adjusted for sampling design. About 30.6% of the participants met at least four out of the five healthy lifestyle factors. In multinomial model, subjects who were female (aOR = 3.26, 95%CI = 2.58, 4.12), of Chinese (aOR = 2.31, 95%CI = 1.62, 3.30 or other ethnicity (aOR = 1.44, 95%CI = 1.05, 1.98), and aged 18–30 years (aOR = 1.74, 95% CI = 1.12, 2.71) showed significant association with achieving healthy lifestyle compared to male, Malay and ≥ 61 years old as reference categories. Our results indicated that gender, age and ethnicity associated with healthy lifestyle behaviours. Information on the influence of socio-demographic factors on the prevalence of healthy lifestyles will facilitate the development of effective intervention strategies to improve the adaptation of healthy lifestyle practices. - PublicationThe burden of premature mortality among older adults: a population-based study in Malaysia(BMC, 2022)
;Yee Mang Chan ;Shubash Shander Ganapathy ;LeeAnn Tan ;Nazirah Alias ;Nur Hamizah NasaruddinWan-Fei KhawBackground: The populations of many countries—including Malaysia—are rapidly growing older, causing a shift in leading causes of disease and death. In such rapidly ageing populations, it is critical to monitor trends in burden of disease and health of older adults by identifying the leading causes of premature mortality and measuring years of life lost (YLL) to these. The objective of this study, therefore, is to describe the burden (quantified by YLL) associated with major causes of premature mortality among older adults in Malaysia in 2019. Methods: All deaths that occurred in older adults aged 60 and above in Malaysia in the year 2019 were included in this study. YLL was calculated by summing the number of deaths for the disease category at 5-year age intervals, multiplied by the remaining life expectancy for the specific age and sex group. Both life expectancy and mortality data were obtained from the Department of Statistics Malaysia. Results: In 2019, older adults accounted for 67.4% of total deaths in Malaysia (117,102 out of 173,746). The total number of YLL among older adults in Malaysia in 2019 was estimated at 1.36 million YLL, accounting for 39.6% of the total YLL (3.44 million) lost to all premature deaths in that year. The major causes of premature mortality among older adults were ischaemic heart disease (29.5%) followed by cerebrovascular disease (stroke) (20.8%), lower respiratory infections (15.9%), diabetes mellitus (8.1%) and trachea, bronchus and lung cancers (5.0%). Conclusions: Non-communicable diseases (NCD) remained the largest contributor to premature mortality among older adults in Malaysia. Implementation of population-level NCD health promotion programmes, screening programmes among high-risk groups and holistic intervention programmes among populations living with NCD are critical in reducing the overall burden of premature mortality