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  1. Home
  2. Browse by Author

Browsing by Author "Rohani M. D. Yasin"

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    Spread of Carbapenem-Resistant Acinetobacter baumannii Global Clone 2 in Asia and AbaR-Type Resistance Islands
    (2013)
    Dae Hun Kim
    ;
    Ji-Young Choi
    ;
    Hae Won Kim
    ;
    So Hyun Kim
    ;
    Doo Ryeon Chung
    ;
    Kyong Ran Peck
    ;
    Visanu Thamlikitkul
    ;
    Thomas Man-Kit So
    ;
    Rohani M. D. Yasin
    ;
    Po-Ren Hsueh
    ;
    Celia C. Carlos
    ;
    Li Yang Hsu
    ;
    Latre Buntaran
    ;
    M. K. Lalitha
    ;
    Jae-Hoon Song
    ;
    Kwan Soo Ko
    In this surveillance study, we identified the genotypes, carbapenem resistance determinants, and structural variations of AbaRtype resistance islands among carbapenem-resistant Acinetobacter baumannii (CRAB) isolates from nine Asian locales. Clonal complex 92 (CC92), corresponding to global clone 2 (GC2), was the most prevalent in most Asian locales (83/108 isolates; 76.9%). CC108, or GC1, was a predominant clone in India. OXA-23 oxacillinase was detected in CRAB isolates from most Asian locales except Taiwan. blaOXA-24 was found in CRAB isolates from Taiwan. AbaR4-type resistance islands, which were divided into six subtypes, were identified in most CRAB isolates investigated. Five isolates from India, Malaysia, Singapore, and Hong Kong contained AbaR3-type resistance islands. Of these, three isolates harbored both AbaR3- and AbaR4-type resistance islands simultaneously. In this study, GC2 was revealed as a prevalent clone in most Asian locales, with the AbaR4-type resistance island predominant, with diverse variants. The significance of this study lies in identifying the spread of global clones of carbapenemresistant A. baumannii in Asia.
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