Browsing by Author "Rohani M. D. Yasin"
Now showing 1 - 1 of 1
Results Per Page
Sort Options
- PublicationSpread of Carbapenem-Resistant Acinetobacter baumannii Global Clone 2 in Asia and AbaR-Type Resistance Islands(2013)
;Dae Hun Kim ;Ji-Young Choi ;Hae Won Kim ;So Hyun Kim ;Doo Ryeon Chung ;Kyong Ran Peck ;Visanu Thamlikitkul ;Thomas Man-Kit So ;Rohani M. D. Yasin ;Po-Ren Hsueh ;Celia C. Carlos ;Li Yang Hsu ;Latre Buntaran ;M. K. Lalitha ;Jae-Hoon SongKwan Soo KoIn this surveillance study, we identified the genotypes, carbapenem resistance determinants, and structural variations of AbaRtype resistance islands among carbapenem-resistant Acinetobacter baumannii (CRAB) isolates from nine Asian locales. Clonal complex 92 (CC92), corresponding to global clone 2 (GC2), was the most prevalent in most Asian locales (83/108 isolates; 76.9%). CC108, or GC1, was a predominant clone in India. OXA-23 oxacillinase was detected in CRAB isolates from most Asian locales except Taiwan. blaOXA-24 was found in CRAB isolates from Taiwan. AbaR4-type resistance islands, which were divided into six subtypes, were identified in most CRAB isolates investigated. Five isolates from India, Malaysia, Singapore, and Hong Kong contained AbaR3-type resistance islands. Of these, three isolates harbored both AbaR3- and AbaR4-type resistance islands simultaneously. In this study, GC2 was revealed as a prevalent clone in most Asian locales, with the AbaR4-type resistance island predominant, with diverse variants. The significance of this study lies in identifying the spread of global clones of carbapenemresistant A. baumannii in Asia.