Vaccination is a humans' resort to protect themselves against diseases which can be regarded as a deliberate attempt to maintain survival. In the earliest centuries where knowledge on infectious microorganisms was indistinct, men had sought desperately to overcome various plagues and pestilences. History has shown a few stages of event involving several scientists and key persons in the development of the first smallpox vaccine in 1798, Edward Jenner is named as the person who holds title to the first scientific attempt to control an infectious disease on a large scale by his work of cowpox vaccination and popularized vaccination thereafter!' However, this way of surviving has exist as early as in the 7 century when some Indian Buddhists drank snake venom in an attempt to become immune to its effect. Details are vague and the explanation was extremely scarce back then but it is understood now that the attempt may have been inducing toxoid-like immunity.