Abstract Ageing is attributed to both genetic and environmental factors. Occupational exposure is one of the environmental factors with potential genotoxic effects. Researchers try to determine factors involved in genetic damages at hazards exposure that could accelerate ageing. Cytochrome P450 2E1 (CYP2E1) gene contributes in activation and detoxification of the environmental hazards. This polymorphism plays an important role in susceptibility of inter-individuals to DNA damage at the occupational exposure. The current study evaluated the possible influence of this gene polymorphism in ageing by genomic damages through the biomarkers alterations of micronuclei (MN), comet tail length and telomere length shortening at the exposure. In this study, buccal cells were collected from the oral cavity of exposed workers and non-exposed controls. The CYP2E1 genotypes were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The wild genotype significantly affected MN frequency (p=0.007) and relative telomere length (p=0.047) in the older group of workers. It was concluded that the interaction of gene polymorphism and exposure enhances DNA damage and accelerates ageing consequently.

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To evaluate the eAicacy and safety of non-pharmacological measures for preventing opportunistic infections in patients with haematological malignancies.

Oil and gas industry is a main revenue generation for Iran, and thousands of employees are involved in various oil and gas fields. From numerous health hazards which commonly occur in the industry one of them is psychosocial hazards. Studies confirmed a crucial step to control and understanding workplace psychosocial risk factors is developing and monitoring of policies, rules, and plans to promote health at work. This research conducted in an Iranian oil and gas company in Tehran in the period of 2011 and 2012. 248 participants were randomly selected and assigned in the study. Two questionnaires HSE and SCAT used in order to assess workplace psychosocial risks and attitude of personnel to safety climate. The result of HSE scores revealed relationships and role sub-scales in psychosocial risks were in abysmal situation. Personnel’s attitude to safety climate at the organization displayed communication, priority of safety, and involvement were at the level of “dissatisfied”. Also there was a medium positive correlation between work environment and managers’ support, relationships and change p<0.01. These findings show that safety climate factors namely communication, work environment, supportive environment, inversely affects workplace psychosocial risks. Overall, the outcomes supported the possibility that personnel attitudes to safety climate at company were predictive of higher psychosocial risks. Progress in safety climate and the psychosocial aspects of safety climate may diminish the experience psychosocial risks. Development of policies and procedures with aim of reduce psychosocial risks should be considered in Iran.

Cervical cancer is the most common malignant cancer of the female reproductive organs worldwide. Currently, cervical cancer can be prevented by vaccination and detected at an early stage via various screening methods. Malaysia, as a developing country faces a heavy disease burden of cervical cancer as it is the second most common cancer among Malaysian women. This population based study was carried out to fulfil the primary aim of determining the survival rates of Malaysian women with cervical cancer and associated factors. Data were obtained from two different sources namely, the Malaysian National Cancer Registry (MNCR) and National Health Informatics Centre (NHIC) from 1st January 2000 to 31st December 2005. Kaplan Meier analyses were conducted to identify the overall survival rates and median survival time. Differences in survival among different ethnic and age group were compared using the log-rank test. A total of 5,859 patients were included. The median survival time for cervical cancer in this study was 65.8 months and the 5-year survival rate was 71.1%. The overall observed survival rates at 1, 3 and 5 years were 94.1%, 79.3% and 71.1% respectively. The log-rank test finding also showed that there were significant differences in the 5-year survival rate among different ethnic groups. Malays had the lowest survival rate of 59.2% followed by Indians (69.5%) and Chinese (73.8%). The overall 5-year survival rate among patients with cervical cancer in Malaysia is relatively good. Age and ethnic groups remain as significant determining factors for cervical cancer survival rate.