Autoinflammatory disorders are characterized by dysregulated innate immune response, resulting in recurrent uncontrolled systemic inflammation and fever. Gain-of-function mutations in NLRC4 have been described to cause a range of autoinflammatory disorders. We report a twelve-year-old Malay girl with recurrent fever, skin erythema, and inflammatory arthritis. Whole exome sequencing and subsequent bidirectional Sanger sequencing identified a heterozygous missense mutation in NLRC4 (NM_001199138: c.1970A > T). This variant was predicted to be damaging in silico, was absent in public and local databases and occurred in a highly conserved residue in the leucine-rich repeat (LRR) domain. Cytokine analysis showed extremely high serum IL-18 and IL 18/CXCL9 ratio, consistent with other NLRC4-MAS patients. In summary, we identified the first patient with a novel de novo heterozygous NLRC4 gene mutation contributing to autoinflammatory disease in Malaysia. Our findings reinforce the likely pathogenicity of specific LRR domain mutations in NLRC4 and expand the clinical spectrum of NLRC4 mutations.

BACKGROUND: Self-efficacy is defined as his or her belief of their capacity to produce specific performance attainments where represent the ability of positive and negative control over their own motivation, behavior, and social environment. Interventions to increase self-efficacy are a potentially effective way of changing health behavior towards attractive results, however the subject has not been systematically reviewed. This review aims to assess the relationship between self-efficacy and change in good health behaviour. METHODS: A comprehensive and extensive search of four bibliographic data bases was conducted for papers reporting health promotion and educational interventions that explicitly targeted self-efficacy in order to change health behaviour in achieving better disease control.RESULTS: Out of 314 studies, 13 were included in the review. Of these, 8 were found to have significant association between self-efficacy and specific health behaviours. However, 5 studies failed to show any significant prediction towards health behavior. Another 6 studies showed either significant mediation effect or indirect relationship of self-efficacy and health behaviours. CONCLUSIONS: Self-efficacy appears to be an important psychosocial construct that may directly or indirectly affect health behaviour to control diseases. Self-efficacy may also function as a link between effective health promotion and educational interventions and health behaviour change in disease control.

Objective: The present review aimed to determine the effect of palm oil ver sus other oils on changes in body weight or Body Mass Index (BMI). Design: A systematic review was conducted. Studies were identified by database searching (EMBASE, PUBMED, CENTRAL, SCOPUS, PROQUEST, Web of Science [ISI Web of Knowledge], Cumulative Index to Nursing and Allied Health Library (CINAHL Plus), LILAC and ClinicalTrials.gov. Searching, se lecting and reporting were done according to the PRISMA (Preferred Report ing Items for Systematic reviews and Meta-Analyses) Statement. Setting: Palm oil vs other oils intervention study on weight or BMI changes. Subjects: Individuals participating in palm oil vs other oil intervention study. Results: A total of 182 studies were screened for eligibility, five studies were finally in cluded. Three studies compared the effect of palm oil vs sunflower oil on weight changes and BMI. One study examined the effect of hybrid palm oil vs extra virgin olive oil on weight changes. The last study examined the effect of palm oil vs olive oil vs lard on weight changes. Out of 292 participants in five studies, only one study (Iggman, 2014) had a low risk of bias. In this study, there was no significant difference between the group that received sunflower oil and palm oil (SMD: 0.04, 95% CI: −0.59 to 0.66). Other four studies had unclear risk of bias. Conclusions: Based on the review, there is insufficient evidence to suggest the impact of palm oil intake on weight changes or BMI.