Browsing by Author "Masliyana Husin"
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- PublicationEffectiveness of COVID-19 vaccines among children 6–11 years against hospitalization during Omicron predominance in Malaysia(2024)
;Vivek Jason Jayaraj ;Masliyana Husin ;Jing Lian Suah ;Peter Seah Keng Tok ;Azahadi Omar ;Sanjay RampalSheamini SivasampuThere is currently limited data on the efectiveness of COVID-19 vaccines for children aged 6–11 years in Malaysia. This study aims to determine vaccine efectiveness (VE) against COVID-19-related hospitalization after receipt of one- and two-doses of BNT162b2 mRNA (Comirnaty-Pfzer/BioNTech) vaccine over a duration of almost 1 year in the predominantly Omicron period of BA.4/BA.5 and X.B.B sub lineages. This study linked administrative databases between May 2022 and March 2023 to evaluate real-world vaccine efectiveness (VE) for the BNT162b2 mRNA (Comirnaty-Pfzer/BioNTech) vaccine against COVID-19-related hospitalization in the Omicron pre-dominant period with BA.4/BA.5 and X.B.B sub lineages. During the Omicron-predominant period, the cumulative hospitalization rate was almost two times higher for unvaccinated children (9.6 per million population) compared to vaccinated children (6 per million population). The estimated VE against COVID-19 hospitalization for one dose of BNT162b2 was 27% (95% CI − 1%, 47%) and 38% (95% CI 27%, 48%) for two doses. The estimated VE against hospitalization remained stable when stratifed by time. VE for the frst 90 days was estimated to be 45% (95% CI 33, 55%), followed by 47% (95% CI 34, 56%) between 90 and 180 days, and 36% (95% CI 22, 45%) between 180 and 360 days. Recent infection within 6 months does not appear to modify the impact of vaccination on the risk of hospitalization, subject to the caveat of potential underestimation. In our pediatric population, BNT162b2 provided moderate-non-diminishing protection against COVID-19 hospitalization over almost 1 year of Omicron predominance. - PublicationHealth-SigQOLM is a versatile scale for measuring various aspects of health-related quality of life(Springer Nature, 2024-06-13)
;Mohamad Adam Bujang ;Wei Hong Lai ;Selvasingam Ratnasingam ;Xun Ting Tiong ;Yoon Khee Hon ;Eileen Pin Pin Yap ;Yvonne Yih Huan Jee ;Nurul Fatma Diyana Ahmad ;Alex Ren Jye KimMasliyana HusinObjective: The “Health” element is one of the elements in Significant Quality of Life Measure (SigQOLM) that measures quality of life and well-being of people. This study aims to evaluate the Health element (Health-SigQOLM) as a generic and dynamic scale to measure health-related quality of life (HRQOL) with a broader spectrum of coverage. This study used a secondary data that developed SigQOLM. Only the “Health” element with 33 items is used for analysis. Results: The construct of Health-SigQOLM has a minimum factor loading of 0.425 with excellent model fit. The health status among healthcare workers is significantly associated with the Health-SigQOLM (p<0.001). The Health-SigQOLM score can clearly distinguish between healthy people and those who have been afflicted with some diseases but have never been hospitalized due to disease progression or other associated complications (p=0.002). The Health-SigQOLM is a generic and dynamic tool for assessing various aspects of health-related quality of life.