Browsing by Author "Lai Seong Hooi"
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- PublicationA population-based study measuring the prevalence of chronic kidney disease among adults in West Malaysia(2013)
;Lai Seong Hooi ;Loke Meng Ong ;Ghazali Ahmad ;Sunita Bavanandan ;Noor Ani Ahmad ;Balkish M. Naidu ;Wan Nazaimoon W MohamudMuhammad Fadhli M YusoffIn this population-based study, we determine the prevalence of chronic kidney disease in West Malaysia in order to have accurate information for health-care planning. A sample of 876 individuals, representative of 15,147 respondents from the National Health and Morbidity Survey 2011, of the noninstitutionalized adult population (over 18 years old) in West Malaysia was studied. We measured the estimated glomerular filtration rate (eGFR) (CKD-EPI equation); albuminuria and stages of chronic kidney disease were derived from calibrated serum creatinine, age, gender and early morning urine albumin creatinine ratio. The prevalence of chronic kidney disease in this group was 9.07%. An estimated 4.16% had stage 1 chronic kidney disease (eGFR 490 ml/min per 1.73 m2 and persistent albuminuria), 2.05% had stage 2 (eGFR 60–89 ml/min per 1.73 m2 and persistent albuminuria), 2.26% had stage 3 (eGFR 30–59 ml/min per 1.73 m2 ), 0.24% had stage 4 (eGFR 15–29 ml/min per 1.73 m2), and 0.36% had stage 5 chronic kidney disease (eGFR o15 ml/min per 1.73 m2). Only 4% of respondents with chronic kidney disease were aware of their diagnosis. Risk factors included increased age, diabetes, and hypertension. Thus, chronic kidney disease in West Malaysia is common and, therefore, warrants early detection and treatment in order to potentially improve outcome. - PublicationPrevalence of chronic kidney disease and its associated factors in Malaysia; findings from a nationwide population-based cross-sectional study(2020)
;Thamil Arasu Saminathan ;Lai Seong Hooi ;Muhammad Fadhli Mohd Yusoff ;Loke Meng Ong ;Sunita Bavanandan ;Wan Shakira Rodzlan Hasani ;Esther Zhao Zhi Tan ;Irene Wong ;Halizah Mat Rifin ;Tania Gayle Robert ;Hasimah Ismail ;Norazizah Ibrahim Wong ;Ghazali Ahmad ;Rashidah Ambak ;Fatimah Othman ;Hamizatul Akmal Abd HamidTahir ArisBackground: The prevalence of chronic kidney disease (CKD) in Malaysia was 9.07% in 2011. We aim to determine the current CKD prevalence in Malaysia and its associated risk factors. Methods: A population-based study was conducted on a total of 890 respondents who were representative of the adult population in Malaysia, i.e., aged ≥18 years old. Respondents were randomly selected using a stratified cluster method. The estimated glomerular filtration rate (eGFR) was estimated from calibrated serum creatinine using the CKD-EPI equation. CKD was defined as eGFR < 60 ml/min/1.73m 2 or the presence of persistent albuminuria if eGFR ≥60 ml/min/1.73m 2. Results: Our study shows that the prevalence of CKD in Malaysia was 15.48% (95% CI: 12.30, 19.31) in 2018, an increase compared to the year 2011 when the prevalence of CKD was 9.07%. An estimated 3.85% had stage 1 CKD, 4.82% had stage 2 CKD, and 6.48% had stage 3 CKD, while 0.33% had stage 4–5 CKD. Hypertension (aOR 3.72), diabetes mellitus (aOR 3.32), increasing BMI (aOR 1.06), and increasing age (aOR 1.06) were significantly associated with CKD. Conclusion: Our study has shown that CKD has become one of the leading public health issues in Malaysia. Thus, there is an urgent need to screen for CKD and prevent its progression, associated morbidity, and mortality at the national level. - PublicationProtocol for a randomised, open-label, parallel group, multicentre controlled study to evaluate the clinical performance and safety of Stay Safe Link compared with Stay Safe in patients with end-stage kidney disease on continuous ambulatory peritoneal dialysis(2019)
;Wen Yao Mak ;Loke Meng Ong ;Bak Leong Goh ;Sunita Bavanandan ;Lily Mushahar ;Chin Tho LeongLai Seong HooiPeritonitis is a major complication of continuous ambulatory peritoneal dialysis (CAPD), the risk of which is significantly influenced by the type of PD transfer system. Although the Y-disconnect and double-bag system is more efficient in preventing peritonitis compared with the spike system, little information is available to differentiate risks between different brands of the Y-disconnect double-bag system. A randomised controlled trial to evaluate the safety and efficacy of a newly introduced system is needed to provide the necessary clinical evidence to guide policy decision-making.