Dengue is a vector borne disease which is one of the major threats to public health in Malaysia. Mapping of dengue distribution in spatial and spatial-temporal aspects can be a useful method in assessing the risk of dengue to the community. This study aimed to map the spatial and spatial-temporal distribution of dengue cases in Seremban district. The Geographical Information System specifically the spatial and spatial-temporal analyses was applied. Spatial statistical analysis of dengue cases used the Moran’s Index, average nearest neighbourhood (ANN) and kernel density estimation. Spatial-temporal analysis was determined through frequency, duration and intensity indices to identify timely dengue risk area. A total of 6076 dengue cases were reported in Seremban Health District Office from 2003-2009. The result showed a high incidence rate in 2003, 2008 dan 2009 with ratio of dengue: dengue hemorrhagic fever of 21.6:1. Moran’s I showed dengue cases occurred in cluster with Z-score of 16.384 (p=0.000). ANN analysis of 0.264 (p= 0.000) where the mean distance between every dengue case is 55 m. Kernel density estimation showed the dengue hotspots concentrated in Nilai and Ampangan. Spatial-temporal analysis with the highest mean of frequency, duration and intensity indices of above 0.023, 0.614 and 0.657 showed that the high risk dengue areas were Nilai, Seremban and Ampangan. The dengue control activities should be targeted at these high risk areas.