Publication: High early pregnancy serum 25-hydroxy vitamin D level, within a sub-optimal range, is associated with gestational diabetes mellitus: a prospective cohort study
dc.contributor.author | Heng Yaw Yong | |
dc.contributor.author | Zalilah Mohd Shariff | |
dc.contributor.author | Lalitha Palaniveloo | |
dc.contributor.author | Su Peng Loh | |
dc.contributor.author | Barakatun Nisak Mohd Yusof | |
dc.contributor.author | Zulida Rejali | |
dc.contributor.author | Jacques Bindels | |
dc.contributor.author | Yvonne Yee Siang Tee | |
dc.contributor.author | Eline M. van der Beek | |
dc.date.accessioned | 2024-07-17T09:01:32Z | |
dc.date.available | 2024-07-17T09:01:32Z | |
dc.date.issued | 2022-02 | |
dc.description.abstract | BACKGROUND/OBJECTIVES: Low early pregnancy serum 25-hydroxy vitamin D (25[OH]D) levels can increase gestational diabetes mellitus (GDM) risk, although inconsistent findings related to that association have been reported. This study examined the association of serum vitamin D with GDM and the possible influencers on this association. SUBJECTS/METHODS: This study included 259 pregnant women within the Seremban Cohort Study (SECOST). Blood samples at < 14 weeks of gestation were drawn to determine serum 25(OH)D levels. GDM diagnosis was made at 24 to 32 weeks of gestation using a standard procedure. Association between serum vitamin D and GDM was tested using binary logistic regression. RESULTS: Nearly all women (90%) had mild (68.3%) or severe (32.2%) vitamin D deficiency (VDD). Non-GDM women with mild VDD had a significantly higher mean vitamin D intake than GDM women with mild VDD (t = 2.04, p < 0.05). Women with higher early pregnancy serum vitamin D levels had a greater risk of GDM. However, this significant association was only identified among those with a family history of type 2 diabetes mellitus (T2DM) and in women with a body mass index indicating overweight or obese status. CONCLUSIONS: The high prevalence of VDD in this sample of pregnant women underscores the need for effective preventive public health strategies. Further investigation of this unexpected association between serum vitamin D level and GDM risk in predominantly VDD pregnant women and the potential effects of adiposity and family history of T2DM on that association is warranted. | |
dc.identifier.doi | https://doi.org/10.4162/nrp.2022.16.1.120 | |
dc.identifier.uri | https://e-nrp.org/DOIx.php?id=10.4162/nrp.2022.16.1.120 | |
dc.identifier.uri | https://repository.nih.gov.my/handle/123456789/579 | |
dc.language.iso | en | |
dc.publisher | The Korean Nutrition Society and the Korean Society of Community Nutrition | |
dc.relation.ispartof | Nutrition Research and Practice | |
dc.relation.issn | 2005-6168 | |
dc.relation.journal | Nutrition Research And Practice | |
dc.subject | Vitamin D | |
dc.subject | gestational diabetes mellitus | |
dc.subject | vitamin D deficiency | |
dc.subject | body mass index | |
dc.title | High early pregnancy serum 25-hydroxy vitamin D level, within a sub-optimal range, is associated with gestational diabetes mellitus: a prospective cohort study | |
dc.type | journal-article | |
dspace.entity.type | Publication | |
oaire.citation.issue | 1 | |
oaire.citation.volume | 16 |
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